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ECT Unit (Electro-Convulsive_Unit)

Model
57800
The ECT apparatus (Electro Convulsive Therapy) is specially designed for neurochemical and neuropharmacological research.
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The ECT apparatus (Electro Convulsive Therapy) is specially designed for neurochemical and neuropharmacological research. 
 
A constant current output is used, which ensures reproducible results and accurate determination of the EC threshold while also pinpointing any variations in the threshold brought about by drugs having a specific action on the cortex and sub-cortical regions. The shock parameters have been selected after consulting the most relevant literature, to supply the most suitable range when operating with mice or rats.                                             
Consistent reproducible current levels are produced by feedback circuitry that adjust for variance in impedance of the contact from animal to animal.
 
The impedance to the animal can be pre-measured and displayed, and a warning signal flashes if the impedance is too great to deliver the desired current level.
 
The standard auricular electrodes supplied (see main picture) allow a single operator to deliver shock to a number of subjects in a short time. Optional corneal electrodes are available as optional.
 
The special output circuit enables any type of electrode to be used.
Corresponding parameter set not found, please add it in property template of background
  • Optional analogue output   
  • Any type of electrode can be used   
  • Feedback circuitry
  • Can be connected to oscilloscope
  • Allows for virtually any procedure
  • Compensates for impedance variability due to animal-electrode contact  
  • M. Svensson et alia: “Effect of Electroconvulsive Seizures on Cognitive Flexibility” Hippocampus 26(7): 899-910, 2016
  • J. Coppens et alia: “Anticonvulsant Effect of a ghrelIn Receptor Agonist in 6Hz Corneally Kindled Mice” Epilepsia 57(9): e195-e199, 2016
  • F. Tomaciello et alia: “Resveratrol Lacks Protective Activity Against Acute Seizures in Mouse Models” Neuroscience Letters 632: 199-203, 2016 (6Hz model)
  •  R.J. Schloesser et alia: “Antidepressant-like Effects of Electroconvulsive Seizures Require Adult Neurogenesis in a Neuroendocrine Model of Depression” Brain Stimulation 8(5): 862–867, 2015
  • A. Kretschmann et alia: “Different MicroRNA Profiles in Chronic Epilepsy Versus Acute Seizure Mouse Models” J. Molecular Neurosc. 55(2): 466-479, 2015
  • O. J. Imoru et alia: “Evaluation of Anticonvulsant Activity of Aqueous Leaf Extract of Telfairia occidentalis in Mice” Eur. J. Medicinal Plants 5.3: 272-280, 2015
  • M. Svensson et alia: “Effect of Electroconvulsive Seizures on Pattern Separation” Hippocampus 00: 1–10, 2015
  • M.J. Benson et alia: “A Novel Anticonvulsant Mechanism Via Inhibition of Complement Receptor C5ar1 in Murine Epilepsy Models” Neurobiology of Disease 76:87-97, 2015 (Corneal Electrodes)
  • L. Walrave et alia: “Validation of the 6 Hertz Refractory Seizure Mouse Model for Intracerebroventricularly Administered Compounds” Epilepsy Research 115: 67-72, 2015 (6Hz model)
  •  K. Leclercq et alia: “Low potency and limited efficacy of antiepileptic drugs in the mouse 6 Hz corneal kindling model” Epilepsy Research 108(4): 675-683, 2014 (6Hz model)
  •  K.M. Ryan et alia: “Electroconvulsive Stimulation Alters Levels of BDNF-associated microRNAs” Neuroscience Letters 549: 125–129, 2013
  • N.K. Thomas et alia: “Triheptanoin in Acute Mouse Seizure Models” Epilepsy Research 99(3): 312-317, 2012
  • S.A. Epps et alia: “Seizure Susceptibility and Epileptogenesis in a Rat Model of Epilepsy and Depression Co-Morbidity” Neuropsychopharmacol. 37: 2756-2763, 2012
  • M. Gasior et alia: “Anticonvulsant and Proconvulsant Actions of 2-deoxy-D-glucose” Epilepsia 1-10, 2010
  • A.L. Hartman et alia: “Efficacy of the Ketogenic Diet in the 6-Hz Seizure Test” Epilepsia 49(2): 334-339, 2008
  • J.E. Ploski et alia: "Electroconvulsive Seizure-Induced Gene Expression Profile of the Hippocampus Dentate Gyrus Granule Cell Layer" J. Neurochemistry 99 (4): 1122-1132, 2006
  • K. Takahashi et alia: "Expression of Ndrg2 in the Rat Frontal Cortex After Antidepressant and Electroconvulsive Treatment" Int. J. Neuropsy-chopharm. 8: 381-389, 2005
  • R.M. Kaminski et alia: “Allopregnanolone Analogs that Positively Modulate GABAA Receptors Protect against Partial Seizures Induced by 6-Hz Electrical Stimulation in Mice” Epilepsia 45(7): 864-867, 2004
  • C.A. Altar et alia: "Electroconvulsive Seizures Regulate Gene Expression of Distinct Neurotrophic Signaling Pathways" J. Neuroscience 24(11): 2667-2677, 2004
暂未实现,敬请期待
暂未实现,敬请期待
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