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Learned Helplessness

Model
47500
The Ugo Basile Set-Up for Learned Helplessness is based on a sophisticated generator of unpredictable random shocks delivered to the grid floor of a rodent box where no escape is possible.
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The Ugo Basile Set-Up for Learned Helplessness is based on a sophisticated generator of unpredictable random shocks delivered to the grid floor of a rodent box where no escape is possible. Electric shocks can be randomized in terms of shock length, interval and complex trains can be programmed.
 
When rodents are exposed to inescapable and unpredictable stress, such as forced swim or inescapable footshock, they often develop deficits in memory and learning tasks (e.g. Active Avoidance), and often show also analgesic reactions (S.I.A. Stress-Induced Analgesia).
 
At the core of the Learned Helplessness system is a dark isolation cube, in which the subject is placed, and a controller. The chamber is outfitted with an electrified grid floor, and connected to the controller which consists of a shock generator, as well as a timer that incorporates timing and randomizing. Shocks can be randomized on the basis of duration as well as by interval between shock events. Also, more complex trains of shocks can be programmed. The system includes a user-friendly reporting software, to collect, visualize and export into spreadsheets the delivered shocks.
 
The Learned Helplessness set-up is part of UB conditioning-cage project; you buy a single touch-screen controller, and manage all UB cages. Ask for details!
 
 
Mouse or Rat cages are available. This system is expandable, for stimulation of up to 4 animals simultaneously. 
 
The users owning Ugo Basile Fear Conditioning system can conduct the Learned Help-lessness test within the FC cages and cubicles, by purchasing and installing the LH soft-ware on their touch-screen controller
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  • Part of the BEEHIVE SYSTEM
  • Maximum Flexibility
  • Randomizable shock pattern (length and interval)
  • Remote Control feature
  • Great Versatility
  • NEW ON THE 2014 VERSION!
  • the electronic unit encompasses all controls for up to 4 animal cages!
  • Configure your own Experimental Schedules on the touch-screen controller
  • Shock trains can be programmed
  • Makes remote service and software upgrades extremely simple!
  • The same controller can manage different conditioning tests. Ask for details! 
  • Endogenous opioids regulate glucocorticoid-dependent stress-coping strategies in mice K. Szklarczyk et alia, Neuroscience 330: 121-137, 2016
  • Opioid-Dependent Regulation of High and Low Fear Responses in two Inbred Mouse Strains K. Szklarczyk et alia,  Behav. Brain Res 292: 95-101, 2015
  • Kademian et alia: “Biphasic effects of adrenal steroid on learned helplessness behavior by inescapable shock” Neuropsychopharmacology 30: 58-66, 2005
  • Guilherme dos Santos et alia: “Antidepressive-like effects of electroacupuncture in rats” Physiology & Behavior 93: 155-159, 2008
  • S.R. Lourenço Joca et alia: “Activation of post-synaptic 5-HT1A receptors in the dorsal hippocampus prevents learned helplessness development” Brain Research 978 (1-2): 177-184, 2003
  • Borsini & Cesana: “Mechanisms of action of flibanserin in the learned helplessness in rats” European Journal of Pharmacology 433: 81-89, 2001
暂未实现,敬请期待
暂未实现,敬请期待
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