NEW Fear Conditioning System - ANYmaze
The UGO BASILE ANY-maze controlled Fear Conditioning System (Fear Conditioning 2.1) automates the two most common fear conditioning paradigms: Contextual Fear Conditioning and Cued fear Conditioning
The detection of freezing is automated and based on video analysis.
The Ugo Basile Fear Conditioning systems are designed to run Pavlovian conditioning experiments on mice or rats. Single-frequency sounds are delivered as neutral or conditioned stimulus (CS). Experimental procedures which contemplate the sound as CS are usually referred to as Cued Fear Conditioning. Electric current from the grid floor is delivered as the naturally aversive, or unconditioned stimulus (US).
Tests are run in an animal cage with a grid floor, whose appearance can be easily altered by attaching patterned contexts on the walls and floor. This allows for the investigation of Contextual Fear Conditioning, in which the CS is not the sound but the visual appearance of the cage (i.e. the context) itself. In this case the animal associates the electric shock to the environment where it was received.
A typical FC-System consists of:
an FC-Unit, encompassing a Sound-Attenuating Box, with ventilating fan, a dual (visible/I.R.) light, a speaker & a USB-camera. Each FC-Unit has an individual controller on-board
an FC-Cage, for mouse or rat, (see ordering information for available models), with electrified floor & context kit (3 floors and 3 sets of patterned walls)
ANY-maze software (FC or full license, from version 6.0, upgrade available)
Animal Cages with Electrified Grid Floor are available in the following models:
46002 Rat Cage, I.D.: 26x26x30(h)cm
46003 Mouse Cage, I.D.: 17x17x25(h)cm
46004 Mouse XL Cage, I.D. 26x26x30(h)cm, with mouse floor
Optional models for tethered animals are available.
Multiple systems, with virtually no limit, are easily assembled by multiplying the number of FC-Units and FC-cages, with no additional multiplexer or interface required.
ANY-maze controls the shocker, the sound generator and the light (I.R. and visible), and automatically detects the animal freezing, reporting information such as: total freezing time, number and duration of freezing episodes, latency times between stimuli and freezing.
NEW to the 2.1 version:
Extremely simple to set-up: just plug a USB cable into a single USB port on the FC-Unit
ANY-maze controls all phases of the test, managing the experimental parameters, detecting the animal response and analyzing the experimental data
An Ugo Basile Fear Conditioning mode is provided in ANY-maze protocol list to facilitate the set-up: by asking some questions about the way you want to set up the cages, the software creates lots of the protocol items for you!
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You own a previous version of our FC-System? No worries: you can easily upgrade it to the new version, and/or add extra units. Ask for details!
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- AUTOMATIC detection of FREEZING also in total darkness
- Specific versions for rats or mice
- Select the most suitable cage: two sizes, available with optional features, such as specific versions for tethered animals, etc.
- NEW to 2.1 version
- Extremely simple to set-up: just plug a USB cable into a single USB port on the FC-Unit
- Multiple Cage Set-up, with virtually no limit in number
- ANY-maze controls all phases of the test, managing the experimental parameters, detecting the animal response and analyzing the experimental data.
- Prior stress promotes the generalization of contextual fear memories: Involvement of the gabaergic signaling within the basolateral amygdala complex CL Bender, A Otamendi, GD Calfa, VA Molina - Progress in Neuro …, 2017
- Sex-and estrus-dependent differences in rat basolateral amygdala SR Blume, M Freedberg, JE Vantrease, R Chan… - Journal of Neuroscience, 2017
- Strain Specific Effects of Low Level Lead Exposure on Associative Learning and Memory in Rats. M Verma, JS Schneider - NeuroToxicology, 2017
- Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice PL Roubertoux, N Baril, P Cau, C Scajola, A Ghata… - Behavior Genetics, 2017
- Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease A Nobili, EC Latagliata, MT Viscomi, V Cavallucci… - Nature Communications, 2017
- GABAergic signaling within the Basolateral Amygdala Complex modulates resistance to the labilization/reconsolidation process PJ Espejo, PDV Ortiz, ID Martijena, VA Molina - Neurobiology of Learning and …, 2017
- Zinc Supplementation in Rats Impairs Hippocampal-Dependent Memory Consolidation and Dampens Post-Traumatic Recollection of Stressful Event” A Contestabile, E Peña-Altamira, M Virgili… - European - Elsevier, 2016
- Effects of Low Level Lead Exposure on Associative Learning and Memory in the Rat: Influences of Sex and Developmental Timing of Exposure DW Anderson, W Mettil, JS Schneider - Toxicology letters - Elsevier, 2016
- Neurological Deficits of an Rps19(Arg67del) Model of Diamond-Blackfan Anaemia A Kubik-Zahorodna, B Schuster, I Kanchev… - Folia Biologica - fb.cuni.cz, 2016
- D. Sierra-Mercado et alia: “Controlled Cortical Impact Before or After Fear Conditioning does not Affect Fear Extinction in Mice” Brain Research 1606: 133-141, 2015
- S. Yusufishaq et alia: "Post-Weaning Social Isolation impairs observational fear conditioning" Behav. Brain Res. 242 (1): 142-149, 2013
- P.F. Fabene et alia: "Video-Based Analysis of Fear Conditioning: A Validation Test" Measuring Behavior 2012(2): 380, 2012
- A. Sirri et alia: “Temporal Gene Expression Profile of the Hippocampus Following Trace Fear Conditioning”Brain Research 1308 , 14-23, 2010
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