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Tail-Flick Unit

Model
37360
The Ugo Basile Tail Flick was designed to measure accurately the nociceptive threshold to infrared heat stimulus on the rat or mouse tail.
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The Ugo Basile Tail Flick was designed to measure accurately the nociceptive threshold to infrared heat stimulus on the rat or mouse tail.
 
The operator starts the stimulus: when the animal feels pain and flicks its tail, a sensor detects it, stops the timer and switches off the bulb. The reaction time of the animal is thus determined nd automatically recorded.
 
The Tail Flick basically consists of an I.R. source, whose radiant energy of adjustable intensity is focused on the animal tail by an embodied parabolic mirror.
 
The rat is held by the operator on the instrument unobstructed upper panel in such a way that its tail, placed over a flush mounted window, receives the I.R. energy. The instrument can be conveniently used to stimulate the mouse tail; when requeired, mouse holders are available as optional.
 
Latency time & Intensity are automatically exported to a memory stick, USB, or serial port. USB Stick & Software included!
 
Corresponding parameter set not found, please add it in property template of background
  • Tail-flick is scored automatically, by a fiber optic
  • USB memory key and software are included 
  • No protruding elements and unobstructed surface 
  • Precise score, free of human variability
  • Works as a stand-alone or connected to the PC
  • Work confortably and get excellent reproducibility
 
 
  •  J.W. Little et alia: “Spinal Mitochondrial-Derived Peroxynitrite Enhances Neuroimmune Activation During Morphine Hyperalgesia and Antinociceptive Tolerance” Pain 154 (7): 978-986, 2013
  • P.J. McLaughlin et alia: “Behavioral Effects of the Novel Potent Cannabinoid CB1 Agonist AM 4054” Pharmacology Biochemistry and Behavior 109: 16-22, 2013
  • T.A. Kosten et alia: “A Morphine Conjugate Vaccine Attenuates the Behavioral Effects of Morphine in Rats” Progr. in Neuro-Psychopharmacol. and Biol. Psychiatry 45: 223–229, 2013
  • T.C. Chen et alia: “Spontaneous inflammatory Pain Model From a Mouse Line With N-ethyl-N-nitrosourea Mutagenesis” J. Biomed. Science 19 (55): 2–15, 2012 
  • J. Walsh et alia: “Disruption of Thermal Nociceptive Behaviour in Mice Mutant for the Schizophrenia-Associated Genes NRG1, COMT and DISC1” Brain Res. 1348: 114-119, 2012 
  • K. Guillemyn et alia: “In vivo Antinociception of Potent mu Opioid Agonist Tetrapeptide Analogues and Comparison with a Compact Opioid Agonist-neurokin 1 Receptor Antagonist Chimera” Molecular Brain 5 (4): 2-11, 2012 
  • A.J. Morrison et alia: “Design, Synthesis, and Structure–Activity Relationships of indole-3-heterocycles as Agonists of the CB1 Receptor” Bioorganic & Medicinal Chemistry Letters 21: 506-509, 2011  
  • M. Spetea et alia: “In vitro and in vivo Pharmacological Profile of the 5-benzyl Analogue of 14-methoxymetopon, a Novel μ Opioid Analgesic with Reduced Propensity to Alter Motor Function” Eur. J. Pharmac. Sciences 41: 125-135, 2010 
  • C.A. Boehm et alia: “Midazolam Enhances the Analgesic Properties of Dexmedetomidine in the Rat” Vet. Anaesthesia and Analgesia 37 (6): 550-556, 2010  
  • M.A. Philips et alia: “Myg1-Deficient Mice Display Alterations in Stress-Induced Responses and Reduction of Sex-Dependent Behavioural Differences” Behav. Brain Res. 207: 182-195, 2010
  • C. Dawson et alia: “ Dexmedetomidine Enhances Analgesic Action of Nitrous Oxide” Anesthesiology 100 (4): 894−904, 2004
  • P. Tolu et alia: “ Effects of Long-Term Acetyl-L-carnitine Administation in Rats: I. Increased Dopamine Output in Mesocorticolimbic Areas and Protection Toward Acute Stress Exposure” Neuropsychopharmacol. 27 (3): 410-420, 2002
  • R. Nadeson et alia: “ Potentiation by Ketamine of Fentanyl Antinociception. I. An Experimental Study in Rats Showing that Ketamine Administered by Non-Spinal Routes Targets Spinal Cord Antinociceptive Systems” Br. J. Anaesthesia 88 (5): 685−691, 2002
  • L. Jasmin et alia: “ The NK1 Receptor mediates Both the Hyperalgesia and the Resistance to Morphine in Mice Lacking Noradrenaline” PNAS 99 (2): 1029−1034, 2002
  • G.L. Fraser et alia: “ Antihyperalgesic Effects of Opioid Agonists in a Rat Model of Chronic Inflammation” Br. J. Pharmacol. 129: 1668−1672, 2000
  • M. Xu et alia: “ Effects of Radolmidine, a Novel α2- Adrenergic Agonist Compared with Dexmedetomidine in Different Pain Models in the Rat” Anesthesiology 93 (2): 473−481, 2000
  • A. Köster et alia: “Targeted Disruption of the Orphanin Fq/Nociceptin Gene Increases Stress Susceptibility and Impairs Stress Adaptation In Mice” Neurobiology 96 (18): 10444-10449, 1999
  • I. Sora et alia: “Opiate Receptor Knockout Mice Define µ Receptor Roles in Endogenous Nociceptive Responses and Morphine-Induced Analgesia” Neurobiology 94: 1544-1549, 1997C.T. Dourish et alia: "The Selective CCK-B Receptor Antagonist L-365,260 Enhances Morphine Analgesia and Prevents Morphine Tolerance in the Rat" Europ. J. Pharmacol. 176: 35-44, 1990
  • P.W. Nance & J. Sawinok: "Substance P-Induced Long-Term Blockade of Spinal Adrenergic Analgesia: Reversal by Morphine and Naloxone" J. Pharmacol. Exp. Therap. Vol. 240, No. 3: 972-977, 1987
暂未实现,敬请期待
暂未实现,敬请期待
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