Wireless Optogenetic Stimulator
High brightness LED and optic fibers are coupled to achieve mW order light power at the tip. Colors can be changed just by swapping the LED optic fiber component
Remote controller accepts trigger signals from a stimulator, and sends the signals to the receiver.
Receiver can be charged and re-used repeatedly, by a dedicated charger.Receiver has two types, pulse and continuous, each for high frequency and continuous stimulation. The remote controller is compatible for both receivers, by switching the mode switch. Pulse receiver flashes the same timing with trigger pulses, whereas continuous receiver alternates on and off upon a new pulse.
Receivers are very small & light weight
Remote controller transmits stimulation signal to the receiver by infrared
Ideal for mice, rats and marmosets
Developed in collaboration with Prof. Akihiro Yamanaka in Nagoya University
Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction.
Roger Marek, Li Xu, Robert K. P. Sullivan, Pankaj Sah
Nature Neuroscience (2018) 21(5):654-658. DOI: 10.1038
Top-down cortical input during NREM sleep consolidates perceptual memory.
Miyamoto D, Hirai D, Fung CCA, Inutsuka A, Odagawa M, Suzuki T, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, Murayama M
Science (2016) 352(6291): 1315-8. DOI: 10.1126
Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear.
Isosaka T, Matsuo T, Yamaguchi T, Funabiki K, Nakanishi S, Kobayakawa R, Kobayakawa K
Cell (2015) 163(5):1153-64
A Top-Down Cortical Circuit for Accurate Sensory Perception.
Manita S, Suzuki T, Homma C, Matsumoto T, Odagawara M, Yamada K, Ota K, Matsubara C, Inutsuka A, Sato M, Ohkura M, Yamanaka A, Yanagawa Y, Nakai J, Hayashi Y, Larkum ME, Murayama M
Neuron (2015) 86:1304-16
The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice.
Sato M, Ito M, Nagase M, Sugimura YK, Takahashi Y, Watabe AM, Kato F
Molecular Brain (2015) 8:22